We have  custom APP that is used internally only, and even though the UAC is disabled it was throwing this annoying error:

The fix is relatively easy, you just have to be cautious as it might cause potential harm.

1. Navigate to: (REGJUMP is your best friend for that!)

HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\Associations

1. Add a new ‘String Value’, call it ‘LowRiskFileTypes’ and give it the value ‘.exe’.

2. Make sure to remove the ‘.exe’ from the ‘HighRiskFileTypes’ list.

3. Reboot.

Again, the warning, it poses extra risk as it will not warn when the user opens another ‘.exe’ file. We have great backups, users only use the same apps and have no rights to install things, so I am comfortable applying it this way.